Which disease coming from the Americas to Europe in the Columbian Exchange had the largest impact in Europe?

Question

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Syphilis had a significant impact on Europe during the Columbian Exchange because it was a new and deadly disease that spread quickly and was difficult to treat. It caused severe physical and mental symptoms, and many people died from it. It also had a social impact because it was associated with promiscuity and was stigmatized. Overall, syphilis had a bigger impact than polio or measles, which were already present in Europe at the time.

Which Disease Coming from the Americas to Europe in the Columbian