The most powerful and most legitimate way of doing multiple comparisons is to plan to do all possible pairwise comparisons prior to the experiment.

Question

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Planning all possible pairwise comparisons prior to the experiment can increase the risk of Type I errors (false positives). Methods like Bonferroni correction or Tukey's HSD are used to control this risk, but the most powerful approach depends on the specific context and goals of the analysis.

The Most Powerful and Most Legitimate Way of Doing Multiple