A 32-Year-Old Man Is Brought to the Emergency Department by Police

A 32-year-old man is brought to the emergency department by police after he fell in an empty parking lot while shouting at people who are not visible.  He hears two distinct voices telling him to kill himself.  The patient frequently perceives voices coming from the radio and television when they are off.  He is certain that special government operatives spy on him and follow him everywhere.  The patient is unable to describe how long his symptoms have been present.  When asked about his psychiatric history, he says he is not ill but has a surgically implanted chip that controls his thoughts.  The patient's medical history is unremarkable and he reports that he does not use alcohol or illicit drugs.  Physical examination is significant for a bruise on his forehead, which he cannot recall acquiring.  Mental status examination shows a flat affect and disconnected thoughts.  Routine laboratory testing, urine toxicology, and a CT scan are obtained.  When contacted, the patient's mother reports that he has been hearing voices since age 12 and recently stopped taking his medication.  Which of the following neuroimaging findings is most likely to be present in this patient?

A) Atrophy of the caudate
B) Enlargement of cerebral ventricles
C) Increased amygdala volume
D) Increased hippocampal volume
E) Increased total brain volume
F) Structural abnormalities in orbitofrontal cortex and striatum