A 31-year-old woman at 12 weeks gestation comes to the office for recurrent headaches. The patient has a history of episodic migraines that typically resolve with nonsteroidal anti-inflammatory drugs; but since becoming pregnant, the headaches have become more severe and frequent. Over the past month, the patient has had 5 migraine headaches with associated nausea and vomiting that required treatment in the emergency department. In addition, she has had to go to a dark room and rest for a few hours before recovering. The patient has no other chronic medical conditions and her only other medication is a daily prenatal vitamin. Temperature is 36.7 C (98 F) , blood pressure is 120/80 mm Hg, and pulse is 76/min. Fetal heart rate is 160/min. Cranial nerves are intact. Deep tendon reflexes are 2+. Strength and sensation are normal in all extremities. Which of the following is the most appropriate preventive therapy for this patient?
A) Doxylamine
B) Ergotamine
C) Propranolol
D) Sertraline
E) Sumatriptan
F) Topiramate
Correct Answer:
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