An elderly client with depression is given trazodone. Which statement by the client indicates that additional teaching is needed?

Question

Quizplus · Accepted Answer

Trazodone (Oleptro), a serotonin modulator, is used to treat major depressive disorders. In addition to affecting serotonin levels, the drug blocks alpha and histamine (H1) receptors. Blockade of alpha receptors can cause orthostatic hypotension similar to that from other alpha blockers (eg, terazosin, tamsulosin) used to treat benign prostatic hyperplasia. Blockade of H1 receptors leads to sedation. Therefore, this drug is particularly effective in treating insomnia associated with depression. However, concurrent intake of other medications or substances that cause sedation can be detrimental; these include benzodiazepines (eg, alprazolam, lorazepam, diazepam), sedating antihistamines (eg, chlorpheniramine, hydroxyzine), and alcohol (Option D). (Option A) Priapism is a known serious side effect of trazodone. A client with an erection lasting several hours should go to the hospital. (Option B) Clients should be advised to rise from supine to standing slowly, in stages, due to the risk of orthostatic hypotension. (Option C) The drug should be taken at bedtime to avoid daytime sedation. Educational objective: Trazodone modulates serotonin levels in the brain. In addition, it blocks alpha and H1 receptors, leading to orthostatic hypotension and sedation, respectively. Priapism is another serious side effect, though rare.

An Elderly Client with Depression Is Given Trazodone