A 22-year-old woman is brought to the emergency department after the sudden onset of shortness of breath. She has cystic fibrosis and, during the past year, has had 3 respiratory exacerbations that have required hospitalization. Current medications include an inhaled bronchodilator, an inhaled corticosteroid, inhaled N-acetylcysteine, and azithromycin. The patient appears chronically ill. Her temperature is 37.9°C (100.2°F) , pulse is 96/min, respirations are 22/min and labored, and blood pressure is 106/64 mm Hg. Chest excursions and tactile fremitus are decreased on the right side. On auscultation of the chest, breath sounds are significantly diminished over the right lung field and diffuse wheezing is heard over the left lung field. Which of the following is most likely responsible for this patient's acute symptoms?
A) Alveolar consolidation due to inflammatory exudate
B) Bronchial obstruction with alveolar air resorption
C) Diffuse constriction of bronchioles
D) Increased dead-space ventilation
E) Loss of intrapleural negative pressure
Correct Answer:
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