A 62-Year-Old Man and His Wife Visit the Office for an Examination

A 62-year-old man and his wife visit the office for an examination of periodic chest discomfort. The doctor introduces herself to the patient and his wife and affirms that he is comfortable and not in any discomfort at the moment. "He brought a list of his prescriptions for you to check," the patient's wife says, "but I'm not sure he takes all of them on a regular basis." Which of the following is the most acceptable method for the physician to begin the medical interview after thanking them for bringing the list?

A) "Have you had trouble remembering to take your medications?"
B) "How will your pain improve if you don't take your medications?"
C) "May I ask your wife to leave for this part of the evaluation?"
D) "What do your episodes of chest pain feel like?"
E) "Why do you think you have difficulties taking your medications regularly?"