A 36-year-old man is taken to the hospital after being discovered barefoot and yelling to himself in the streets. Despite the fact that he takes antipsychotic medicine on a regular basis, his parents are having problems controlling him at home. The patient feels he is fighting a conspiracy and that a gadget placed in his brain during a previous illness is directly controlling his thoughts. Previous studies with haloperidol, quetiapine, and risperidone yielded very minor improvements. He doesn't have any other medical issues. The patient is awake and restless on mental state evaluation, with poor grooming, unkempt attire, and a flat attitude. He refuses to answer most inquiries, accuses his parents of being involved in the plot, and mumbles incomprehensible gibberish.Which of the following medications would be most effective for this patient's illness?

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Eductional Objective: Clozapine, an antipsychotic, is the medicine of choice for treatment-resistant schizophrenia. Because of the hazards of neutropenia and agranulocytosis, the absolute neutrophil count must be monitored during treatment.

A 36-Year-Old Man Is Taken to the Hospital After Being