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At 12 Weeks Gestation, a 40-Year-Old Woman with Gravida 5

Question 59

Multiple Choice

At 12 weeks gestation, a 40-year-old woman with gravida 5, para 0, aborta 4, presents to the emergency department with vaginal bleeding, midline pelvic discomfort, and severe nausea and vomiting. She has had four previous first-trimester miscarriages. A 16-week-sized uterus is discovered during a pelvic check. A vaginal speculum examination reveals dark crimson blood. A -hCG level of more than 100,000 mIU/mL is detected, and an ultrasound reveals no baby and a uterine cavity filled with many tiny cysts. In the operating theater, the patient undergoes dilatation and curettage, and a friable mass of tissue composed of multiple thin-walled cysts is evacuated from her uterus. Which of the following karyotypes would most likely be revealed by tissue examination?


A) 46,XX
B) 46,XY
C) 47,XXX
D) 47,XXY
E) 69,XXX
F) 69,XXY

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