A research is being conducted to evaluate the effectiveness of spironolactone in patients with heart failure. For two years, 450 patients are given either spironolactone or a placebo. Neither the patients nor the doctors are aware of who is taking the medicine or the placebo. The above-mentioned study design is most successful in preventing:

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Eductional Objective: Clinical studies frequently employ the blinding strategy. The blindness might involve only patients or both patients and physicians (double blinding). The primary goal of blinding is to prevent patient or researcher expectation from interfering with outcome assessment. For example, a researcher's expectation of a favorable outcome among treated patients may result in observer bias.

A Research Is Being Conducted to Evaluate the Effectiveness of Spironolactone