In a reference sample of hundreds of healthy subjects, the laboratory reference range for a novel marker of cardiac injury is 0.04-0.08 U/mL at the standard 95% level of probability. The marker has very high sensitivity and specificity for myocardial tissue. The clinical cardiology team would like to use a 99.7% reference range to assess patients who come to the emergency department with chest pain and have a high pretest probability of cardiac ischemia. An elevated value of the marker is defined as exceeding the 99.7th percentile of the reference sample. Assuming a normal (Gaussian) distribution with a mean of 0.06 U/mL, which of the following most closely approximates the corresponding reference range?
A) 0) 03 to 0.09
B) 0) 035 to 0.085
C) 0) 045 to 0.075
D) 0) 05 to 0.07
E) 0) 055 to 0.065
Correct Answer:
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