A 5-year-old girl is brought to the office by her mother because she is concerned that her daughter "sunburns too easily." The mother says the patient's skin becomes red and scaly with only minimal sun exposure. She first noticed the problem when her daughter was 7 months old during a trip to the beach. The mother has since avoided exposing her child to excess sunlight, but finds it difficult now that the patient has begun kindergarten. Physical examination shows thin and hyperpigmented skin. She also has a few nevi on her hands that have been enlarging rapidly. This patient's disorder is most likely due to a primary defect involving which of the following processes?

Question

A 5-year-old girl is brought to the office by her mother because she is concerned that her daughter "sunburns too easily."  The mother says the patient's skin becomes red and scaly with only minimal sun exposure.  She first noticed the problem when her daughter was 7 months old during a trip to the beach.  The mother has since avoided exposing her child to excess sunlight, but finds it difficult now that the patient has begun kindergarten.  Physical examination shows thin and hyperpigmented skin.  She also has a few nevi on her hands that have been enlarging rapidly.  This patient's disorder is most likely due to a primary defect involving which of the following processes?

Quizplus · Accepted Answer

Eductional Objective: Xeroderma pigmentosum develops due to a defect in nucleotide excision repair.  This disease is characterized by increased sensitivity to ultraviolet radiation and a high incidence of cutaneous malignancy.

A 5-Year-Old Girl Is Brought to the Office by Her