A 65-year-old woman arrives at the emergency room complaining of growing weariness and lower-extremity paresthesias. Otherwise, the patient's medical history is minimal, and he or she does not take any drugs. According to laboratory findings, the average corpuscular volume is 112 fL. Upper gastrointestinal endoscopy reveals atrophic mucosa in the stomach body and fundus, as well as a normal antrum. Which of the following stomach layers is most likely to blame for this patient's symptoms?

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Eductional Objective: Pernicious anemia is an autoimmune illness induced by the cell-mediated death of parietal cells in the gastric body's superficial upper glandular layer and fundus. Parietal cells are in charge of secreting hydrochloric acid and intrinsic factor, a glycoprotein involved in B₁₂ absorption. Megaloblastic anemia and neurologic impairment result from deficiency.

A 65-Year-Old Woman Arrives at the Emergency Room Complaining of Growing