A 30-year-old man comes to the physician for follow-up evaluation for episodic throbbing headaches, palpitations, and paroxysmal sweating. He was adopted shortly after birth and does not know his biological parents. Blood pressure is 160/90 mm Hg. He appears pale but physical examination is otherwise unremarkable. The patient is found to have a neoplastic mass producing excessive amounts of hormones that are causing her symptoms. Surgical resection of the abnormal tissue is performed with no operative complications. Microscopic examination of the tumor cells shows electron-dense, membrane-bound secretory granules. Immunohistochemistry is positive for synaptophysin, chromogranin, and neuron-specific enolase. The abnormal tissue most likely originated from which of the following?
A) Adrenal cortex
B) Adrenal medulla
C) Ovary
D) Parathyroid gland
E) Thyroid follicles
Correct Answer:
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