A 24-year-old woman arrives at the clinic with a pruritic rash on her arms and legs that has been present on and off for the majority of her life. As seen in the exhibit, erythematous patches and papules are found on the posterior left leg. A similar rash is present on the right leg and bilateral antecubital fossae. Which of the following cytokines primarily initiated her current exacerbation?

Question

A 24-year-old woman arrives at the clinic with a pruritic rash on her arms and legs that has been present on and off for the majority of her life. As seen in the exhibit, erythematous patches and papules are found on the posterior left leg.   A similar rash is present on the right leg and bilateral antecubital fossae.  Which of the following cytokines primarily initiated her current exacerbation?

Quizplus · Accepted Answer

Eductional Objective: Atopic dermatitis causes dry, erythematous patches or papules that are exacerbated by a Th2-biased immune response. Th2 cytokines (for example, IL-4 and IL-13) increase IgE synthesis while suppressing epidermal barrier component expression and impairing host immune responses to subsequent microbial infections.

A 24-Year-Old Woman Arrives at the Clinic with a Pruritic