A 2-year-old boy is brought to the office due to recurrent infections. He was born at term after an uncomplicated pregnancy. His mother states, "My boy is always sick with something and is constantly on antibiotics." The patient has had multiple episodes of otitis media, skin infections, and pneumonia. Incision and drainage of his skin infections revealed Staphylococcus aureus on bacterial culture but no purulence. The infections usually resolve with prolonged antibiotic courses. Laboratory testing reveals absent CD18 antigens on the surface of leukocytes. This patient's underlying condition is most likely associated with which of the following?

Question

A 2-year-old boy is brought to the office due to recurrent infections.  He was born at term after an uncomplicated pregnancy.  His mother states, "My boy is always sick with something and is constantly on antibiotics."  The patient has had multiple episodes of otitis media, skin infections, and pneumonia.  Incision and drainage of his skin infections revealed Staphylococcus aureus on bacterial culture but no purulence.  The infections usually resolve with prolonged antibiotic courses.  Laboratory testing reveals absent CD18 antigens on the surface of leukocytes.  This patient's underlying condition is most likely associated with which of the following?

Quizplus · Accepted Answer

Eductional Objective: Leukocyte adhesion deficiency is due to the absence of CD18 antigens, which are necessary for the formation of integrins.  Failure of leukocyte adhesion and migration results in recurrent skin and mucosal infections without purulence, delayed umbilical cord separation, and peripheral leukocytosis.

A 2-Year-Old Boy Is Brought to the Office Due to Recurrent