A 43-year-old man is hospitalized with recent-onset oliguria and a high serum creatinine level. He has been seen in clinic several times for an intranasal ulcer that has failed to heal. This patient's condition is most likely associated with antibodies against which of the following?

Question

A 43-year-old man is hospitalized with recent-onset oliguria and a high serum creatinine level.  He has been seen in clinic several times for an intranasal ulcer that has failed to heal.  This patient's condition is most likely associated with antibodies against which of the following?

Quizplus · Accepted Answer

Eductional Objective: Necrotizing vasculitis of the upper and lower respiratory tract (causing nasal ulcerations, sinusitis, hemoptysis) and rapidly progressive glomerulonephritis-producing a variable degree of renal failure-is characteristic of granulomatosis with polyangiitis (Wegener).  This disease is associated with C-ANCAs, which may target neutrophil proteinase 3.

A 43-Year-Old Man Is Hospitalized with Recent-Onset Oliguria and a High