A mother of a 12-month boy is calling the office due to a concern of her son temperature after a he received the first dose of the subcutaneous measles-mumps-rubella vaccine. His temperature is 38 C (100.4 F) and has been irritable since the vaccination. He has had no prior vaccine-related adverse events. He has no known allergies. The immunization site is mildly red, swollen, and tender; there is no other skin rash. Which of the following cells and effector mechanisms is most likely involved in pathogenesis of this patient's current condition?

Question

A mother of a 12-month boy is calling the office due to a concern of her son temperature after a he received the first dose of the subcutaneous measles-mumps-rubella vaccine. His temperature is 38 C (100.4 F) and has been irritable since the vaccination.  He has had no prior vaccine-related adverse events.  He has no known allergies.  The immunization site is mildly red, swollen, and tender; there is no other skin rash.  Which of the following cells and effector mechanisms is most likely involved in pathogenesis of this patient's current condition?

Quizplus · Accepted Answer

Eductional Objective: Vaccine reactogenicity is a local (eg, warmth, swelling, edema) and systemic (eg, fatigue, fever, headache) inflammatory reaction to the vaccine due to the innate immune response.  It is primarily caused by pattern recognition receptors present on the surface of macrophages and mast cells, which identify the antigen and release inflammatory cytokines (eg, IL-1, IL-6).

A Mother of a 12-Month Boy Is Calling the Office