A 62-year-old man arrives to the office with a severe pruritic face rash that has persisted for three days. The patient does not use any face cosmetics but has coloured his hair regularly in the last year; he recently dyed his hair 5 days ago and recalls experiencing a similar reaction the prior time he used hair dye. The patient has a history of asthma, high blood pressure, and type 2 diabetes. He does not smoke, drink, or use illegal drugs. The vital indicators are within normal ranges. The presentation depicts the results of the physical examination. Which of the following are primarily involved in the pathogenesis of this patient's rash?

Question

A 62-year-old man arrives to the office with a severe pruritic face rash that has persisted for three days. The patient does not use any face cosmetics but has coloured his hair regularly in the last year; he recently dyed his hair 5 days ago and recalls experiencing a similar reaction the prior time he used hair dye. The patient has a history of asthma, high blood pressure, and type 2 diabetes. He does not smoke, drink, or use illegal drugs. The vital indicators are within normal ranges. The presentation depicts the results of the physical examination.  Which of the following are primarily involved in the pathogenesis of this patient's rash?

Quizplus · Accepted Answer

Eductional Objective: Allergic contact dermatitis is a hypersensitivity response of type IV (delayed type). Langerhans cells first deliver haptens to naïve T cells, resulting in clonal proliferation. Sensitized CD8+ T lymphocytes are attracted to the skin and kill tissue upon reexposure. T cell release of interferon gamma augments the immunological response.

A 62-Year-Old Man Arrives to the Office with a Severe