A 68-year-old man comes to the emergency department with a 2-day history of fever, chills, and productive cough. His temperature is 38.9 C (102 F), blood pressure is 108/52 mm Hg, pulse is 102/min, and respirations are 26/min. Crackles and bronchial breath sounds are heard over the right lower lung. There is dullness to percussion over the same area. Chest x-ray reveals right lower lobe consolidation and a right-sided pleural effusion. The patient is started on the appropriate treatment, and a diagnostic thoracentesis is performed that shows an uncomplicated parapneumonic effusion. When a sterile sample of the inflammatory exudate is experimentally introduced into normal human tissue, rapid neutrophil locomotion is observed. Which of the following components of the exudate is most likely responsible for this observed effect?

Question

A 68-year-old man comes to the emergency department with a 2-day history of fever, chills, and productive cough.  His temperature is 38.9 C (102 F), blood pressure is 108/52 mm Hg, pulse is 102/min, and respirations are 26/min.  Crackles and bronchial breath sounds are heard over the right lower lung.  There is dullness to percussion over the same area.  Chest x-ray reveals right lower lobe consolidation and a right-sided pleural effusion.  The patient is started on the appropriate treatment, and a diagnostic thoracentesis is performed that shows an uncomplicated parapneumonic effusion.  When a sterile sample of the inflammatory exudate is experimentally introduced into normal human tissue, rapid neutrophil locomotion is observed.  Which of the following components of the exudate is most likely responsible for this observed effect?

Quizplus · Accepted Answer

Eductional Objective: Leukotriene B₄ stimulates neutrophil migration to sites of inflammation. Other important chemotactic agents include 5-HETE (leukotriene precursor), complement component C5a, and IL-8.

A 68-Year-Old Man Comes to the Emergency Department with a 2-Day