A scientist is interested in the mechanisms by which leukocytes traffic to sites of inflammation and infection. She finds that endothelial cells increase the expression of certain cell surface molecules in response to cytokines to allow for leukocyte trafficking. She subsequently creates a knockout mouse that has a deletion in the platelet endothelial cell adhesion molecule 1 (PECAM-1) gene. The protein product of this gene is mainly localized to specific areas on the endothelial cells. Absent expression of this gene will most likely affect which of the following neutrophil functions?

Question

A scientist is interested in the mechanisms by which leukocytes traffic to sites of inflammation and infection.  She finds that endothelial cells increase the expression of certain cell surface molecules in response to cytokines to allow for leukocyte trafficking.  She subsequently creates a knockout mouse that has a deletion in the platelet endothelial cell adhesion molecule 1 (PECAM-1) gene.  The protein product of this gene is mainly localized to specific areas on the endothelial cells.  Absent expression of this gene will most likely affect which of the following neutrophil functions?

Quizplus · Accepted Answer

Eductional Objective: Inflammation is characterized by the passage of circulating inflammatory leukocytes into the inflamed tissue.  The steps involved include margination, rolling, activation, tight adhesion and crawling, and transmigration.

A Scientist Is Interested in the Mechanisms by Which Leukocytes