The acidification of lysosomes within antigen presenting cells is prevented in an experimental setting. The affected cells show impaired interaction with T lymphocytes upon antigen exposure. The observed effect most likely results from a low cell surface expression of which of the following molecules?

Question

The acidification of lysosomes within antigen presenting cells is prevented in an experimental setting.  The affected cells show impaired interaction with T lymphocytes upon antigen exposure.  The observed effect most likely results from a low cell surface expression of which of the following molecules?

Quizplus · Accepted Answer

Eductional Objective: MHC class II is expressed on the surface of antigen presenting cells (APC) and presents extracellular antigens to T cells after extracellular protein is degraded within acidified lysosomes.  Failure to acidify lysosomes would lead to deficient expression of MHC class II-antigen complexes with subsequent impaired interaction between APCs and T cells.

The Acidification of Lysosomes Within Antigen Presenting Cells Is Prevented