Researchers are studying various cellular processes in normal and diseased states to find new anticancer drug targets. They develop a medication that inhibits an intracellular enzyme that converts adenosine to inosine. With drug use, accumulation of enzyme substrates in the neoplastic cells leads to DNA strand breaks and subsequent apoptosis. Which of the following malignancies is likely to be most responsive to this medication?

Question

Researchers are studying various cellular processes in normal and diseased states to find new anticancer drug targets.  They develop a medication that inhibits an intracellular enzyme that converts adenosine to inosine.  With drug use, accumulation of enzyme substrates in the neoplastic cells leads to DNA strand breaks and subsequent apoptosis.  Which of the following malignancies is likely to be most responsive to this medication?

Quizplus · Accepted Answer

Eductional Objective: Adenosine deaminase (ADA) inhibition/absence is highly lymphocytotoxic.  Medications that block ADA are used to treat lymphocyte-derived cancers.  Inherited gene mutations in ADA lead to the autosomal recessive disease of severe combined immunodeficiency.

Researchers Are Studying Various Cellular Processes in Normal and Diseased