A 12-month-old boy is evaluated for an eczematous rash. Medical history is significant for several severe respiratory infections that required hospitalization. Complete blood count shows white blood cells at 9,000/mm³ and platelets at 40,000/mm³. The platelets seem abnormally small and deformed on the peripheral blood smear. Which of the following is the most likely diagnosis?

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Quizplus · Accepted Answer

Eductional Objective: Wiskott-Aldrich syndrome is characterized by the triad of eczema, thrombocytopenia, and combined B and T cell deficiency.  Patients can have thrombocytopenia at birth, with eczema and repeated infections due to encapsulated and/or opportunistic organisms usually developing later around 6 to 12 months of age.

A 12-Month-Old Boy Is Evaluated for an Eczematous Rash