A 71-year-old man with chronic obstructive pulmonary disease (COPD) is hospitalized due to shortness of breath and wheezing. The patient is treated with bronchodilators and systemic corticosteroids for acute COPD exacerbation. His symptoms improve over the next 2 days. Before being discharged, an intramuscular vaccine containing inactivated viral components, which he normally receives annually, is administered. Several weeks later, the patient comes in close contact with an individual infected with the same virus contained in the vaccine. Which of the following is most likely to occur in this patient as a result of the vaccination?

Question

A 71-year-old man with chronic obstructive pulmonary disease (COPD) is hospitalized due to shortness of breath and wheezing.  The patient is treated with bronchodilators and systemic corticosteroids for acute COPD exacerbation.  His symptoms improve over the next 2 days.  Before being discharged, an intramuscular vaccine containing inactivated viral components, which he normally receives annually, is administered.  Several weeks later, the patient comes in close contact with an individual infected with the same virus contained in the vaccine.  Which of the following is most likely to occur in this patient as a result of the vaccination?

Quizplus · Accepted Answer

Eductional Objective: Inactivated (killed or component) viral vaccines primarily generate a humoral immune response against extracellular viral antigens, preventing viral entry into the cell.  In contrast, live attenuated viral vaccines can generate a strong cell-mediated immune response that can kill virally-infected cells, in addition to providing humoral immunity.

A 71-Year-Old Man with Chronic Obstructive Pulmonary Disease (COPD) Is