A 28-year-old man comes to the emergency department after sustaining an accidental penetrating injury to the left eye. Examination shows left globe perforation with decreased visual acuity. The right eye is normal. The patient is otherwise healthy. Surgical treatment is performed with subsequent improvement in vision. Two months later, the patient experiences pain, photophobia, and diminished vision in the right eye. Evaluation shows leukocytes in the anterior chamber and vitreous humor and choroidal deposits consistent with granulomatous panuveitis. Disruption of which of the following immune processes is most likely responsible for this patient's current condition?

Question

A 28-year-old man comes to the emergency department after sustaining an accidental penetrating injury to the left eye.  Examination shows left globe perforation with decreased visual acuity.  The right eye is normal.  The patient is otherwise healthy.  Surgical treatment is performed with subsequent improvement in vision.  Two months later, the patient experiences pain, photophobia, and diminished vision in the right eye.  Evaluation shows leukocytes in the anterior chamber and vitreous humor and choroidal deposits consistent with granulomatous panuveitis.  Disruption of which of the following immune processes is most likely responsible for this patient's current condition?

Quizplus · Accepted Answer

Eductional Objective: Traumatic injury to the eye, an area of the body that has inherent immune privilege, can lead to the release of previously sequestered antigens that T cells recognize as foreign.  This can lead to subsequent inflammation and blindness in both the injured and uninjured eye.

A 28-Year-Old Man Comes to the Emergency Department After Sustaining