A 10-week-old boy is brought to the office for a follow-up visit. As part of his routine immunization schedule, the patient received the first dose of the Haemophilus influenzae type b (Hib) conjugate vaccine when he was 8 weeks old. However, following vaccine administration, he developed anaphylaxis, requiring epinephrine administration and hospitalization. As a result, the decision was made not to administer additional doses of the Hib vaccine. The patient was born full-term by uncomplicated vaginal delivery and has otherwise been healthy. Physical examination is unremarkable. His older brother has completed the full vaccination course. This patient is at highest risk of which of the following infections compared to his brother?

Question

A 10-week-old boy is brought to the office for a follow-up visit.  As part of his routine immunization schedule, the patient received the first dose of the Haemophilus influenzae type b (Hib) conjugate vaccine when he was 8 weeks old.  However, following vaccine administration, he developed anaphylaxis, requiring epinephrine administration and hospitalization.  As a result, the decision was made not to administer additional doses of the Hib vaccine.  The patient was born full-term by uncomplicated vaginal delivery and has otherwise been healthy.  Physical examination is unremarkable.  His older brother has completed the full vaccination course.  This patient is at highest risk of which of the following infections compared to his brother?

Quizplus · Accepted Answer

Eductional Objective: The Haemophilus influenzae type b (Hib) vaccine induces anticapsular antibodies that facilitate complement-mediated phagocytosis of the bacterium.  The vaccination series has drastically reduced the incidence of invasive disease caused by Hib, such as meningitis, bacteremia, pneumonia, and epiglottitis.

A 10-Week-Old Boy Is Brought to the Office for a Follow-Up