A 7-year-old girl is brought to the office due to a diffuse rash. The father says she developed a lace-like, erythematous rash this morning on her stomach, back, and extremities. Two days ago, the girl developed red, flushed cheeks. She also had congestion, headache, and a low-grade fever for 3 days earlier this week. Last week, her younger brother had similar symptoms that resolved spontaneously. The infectious agent most likely responsible for this patient's disease replicates in progenitors of which of the following cell lines?

Question

A 7-year-old girl is brought to the office due to a diffuse rash.  The father says she developed a lace-like, erythematous rash this morning on her stomach, back, and extremities.  Two days ago, the girl developed red, flushed cheeks.  She also had congestion, headache, and a low-grade fever for 3 days earlier this week.  Last week, her younger brother had similar symptoms that resolved spontaneously.  The infectious agent most likely responsible for this patient's disease replicates in progenitors of which of the following cell lines?

Quizplus · Accepted Answer

Eductional Objective: Erythema infectiosum (fifth disease) is caused by parvovirus B19 and presents with a nonspecific prodrome (eg, malaise, fever, congestion) followed by a classic "slapped-cheek" facial rash and a lacy, reticular body rash.  Parvovirus is highly tropic for erythroid precursor cells and replicates predominantly in the bone marrow.

A 7-Year-Old Girl Is Brought to the Office Due to a Diffuse