A 2-month-old boy is brought to the clinic for irritability, poor feeding, and frequent vomiting. Weight is at the 15th percentile, and head circumference is at the 96th percentile. Lung sounds are clear throughout, and heart auscultation reveals no murmurs. The abdomen is soft and nondistended. There is hepatosplenomegaly. Diffusely reduced muscle tone is present in all extremities. Funduscopy reveals white-yellow chorioretinal lesions in both eyes. MRI of the brain shows enlarged ventricles and scattered intracranial calcifications. Which of the following is the most likely cause of this patient's condition?

Question

A 2-month-old boy is brought to the clinic for irritability, poor feeding, and frequent vomiting.  Weight is at the 15th percentile, and head circumference is at the 96th percentile.  Lung sounds are clear throughout, and heart auscultation reveals no murmurs.  The abdomen is soft and nondistended.  There is hepatosplenomegaly.  Diffusely reduced muscle tone is present in all extremities.  Funduscopy reveals white-yellow chorioretinal lesions in both eyes.  MRI of the brain shows enlarged ventricles and scattered intracranial calcifications.  Which of the following is the most likely cause of this patient's condition?

Quizplus · Accepted Answer

Eductional Objective: Congenital toxoplasmosis is an infection acquired in utero that can present with hydrocephalus, intracranial calcifications, and chorioretinitis due to prolonged CNS inflammation.

A 2-Month-Old Boy Is Brought to the Clinic for Irritability