A 44-year-old man comes to the physician for a follow-up examination. Two months ago, he was diagnosed with HIV infection and antiretroviral treatment was begun. He feels well. He does not smoke or drink alcohol. Current medications include integrase inhibitor. Which of the following steps of viral replication is most likely to be inhibited as a result of this patient's treatment?

Question

A 44-year-old man comes to the physician for a follow-up examination. Two months ago, he was diagnosed with HIV infection and antiretroviral treatment was begun. He feels well. He does not smoke or drink alcohol. Current medications include integrase inhibitor.   Which of the following steps of viral replication is most likely to be inhibited as a result of this patient's treatment?

Quizplus · Accepted Answer

Eductional Objective: Integration of double-stranded HIV DNA into the host cell's chromosomes is necessary to induce viral gene expression and prevent degradation of the viral genome.  Raltegravir is an integrase inhibitor that disrupts HIV genome integration, preventing synthesis of viral mRNA.

A 44-Year-Old Man Comes to the Physician for a Follow-Up