Question: A 4-month-old girl is brought to the routine check-up by her father. It was found that she has left-sided absent red pupillary reflex. Her father was found to have retinal neoplasm in his right eye, and it was enucleated. This patient is at the greatest risk of developing which of the following neoplasms?

Question

Quizplus · Accepted Answer

Eductional Objective: 
The two-hit theory is involved in the pathophysiology of familial retinoblastoma is caused by mutations affecting every single copy of the Rb genes. Patients with such mutations are at increased risk of secondary tumors like osteosarcomas.

Question: a 4-Month-Old Girl Is Brought to the Routine Check-Up