A 70-year-old woman presented to the office complaining of exertional dyspnea of 3 months duration. The patient is complaining of fatigue and generalized edema. She is a known case of systematic lupus erythematosus for 15 years. Temperature is 36.9 C (98.4 F), blood pressure is 118/77 mm Hg, and pulse is 90/min. On examination, there are no enlarged lymph nodes. Cardiopulmonary examination shows decreased breath sounds over the lung bases. An oral ulcer and facial rash are observed during examination. Both legs have pitting edema up to the knees. Urine analysis shows 4+ protein but is otherwise normal. Which of the following would appear on the histological examination of this patient's kidney?

Question

Quizplus · Accepted Answer

Eductional Objective: Serum amyloid A is produced in chronic inflammatory diseases and could accumulate in multiple tissues leading to AA amyloidosis. Patients present with proteinuria due to nephrotic syndrome, which is the most common presentation. The histological examination would show amorphous pink deposits with apple-green birefringence with congo red stain, under the polarized light.

A 70-Year-Old Woman Presented to the Office Complaining of Exertional