A 40-year-old woman presented to the office complaining of excessive thirst and urination in the last month. 4 months ago, the patient had surgery for a brain tumor. Her urine osmolality after 4 hours of water restriction is 230 mOsml/L, increased to 700 mOsm/L after desmopressin administration. The patient is started on desmopressin, her symptoms have resolved. Over the next year, the patient could not wean the medication, and her condition has been permanent. This presentation is best explained by injury to which of the following structures?

Question

Quizplus · Accepted Answer

Eductional Objective: The antidiuretic hormone is produced in the hypothalamus and released from the posterior pituitary. Injuries to these regions lead to diabetes insipidus. Posterior pituitary injuries tend to be transient, while hypothalamic injuries are permanent.

A 40-Year-Old Woman Presented to the Office Complaining of Excessive