A 15-Year-Old Girl Comes to the Physician with Her Father

A 15-year-old girl comes to the physician with her father for evaluation of her tall stature. She is concerned because she is taller than all of her friends. Her birth weight and height were within normal limits. Her father is 174 cm (5 ft 7 in) tall; her mother is 162 cm (5 ft 3 in) tall. She is at the 99th percentile for height and at the 90th percentile for weight.  She has not had her menstrual period yet. .  The patient says that she feels well except for excessive sweating. Her mother has Graves disease. Vital signs are within normal limits. On physical examination, she has long extremities with large hands and feet; the lower jaw is protruding.  Heart sounds are normal.  Sexual development is Tanner stage 4.  Which of the following is the most likely underlying cause of this patient's condition?

A) Aneuploidy of the X chromosome
B) De novo mutation in the fibrillin-1 gene
C) Defective growth hormone receptor
D) Excessive liver production of IGF-1
E) Excessive thyroxine production
F) Increased hypothalamic release of IGF-1
G) Increased pituitary gonadotropin release