A 18-year-old male is examined because he has had lower extremities pain for three months. The discomfort is constant and is felt day and night. He has no history of leg trauma, a fever, or chills. The distal femur has an expansile lesion, as shown on imaging. Following a surgical resection, the specimen is displayed below. Mutations involving which of the following genes are most likely present in this patient?

Question

A 18-year-old male is examined because he has had lower extremities pain for three months. The discomfort is constant and is felt day and night. He has no history of leg trauma, a fever, or chills. The distal femur has an expansile lesion, as shown on imaging. Following a surgical resection, the specimen is displayed below.  Mutations involving which of the following genes are most likely present in this patient?

Quizplus · Accepted Answer

Eductional Objective: The most frequent primary bone cancer in children and young adults is osteosarcoma. Localized pain and edema are the symptoms that are most usually present at the metaphyses of long bones. Hereditary retinoblastoma gene (RB1) and TP53 mutations are linked to the majority of cases (Li-Fraumeni syndrome).

A 18-Year-Old Male Is Examined Because He Has Had Lower