A 17-year-old boy is brought to the physician because of a 12-day history of increasing pain and swelling of his right knee. For the past 3 weeks, he has experienced episodes of pain when urinating. He had a painful, swollen left ankle joint that resolved without treatment one week ago. His mother has rheumatoid arthritis. He is sexually active with 2 female partners and uses condoms inconsistently. He appears anxious. This patient's condition is most likely associated with which of the following?

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Eductional Objective: The classic triad of reactive arthritis is nongonococcal urethritis, conjunctivitis, and arthritis.  It is an HLA-B27-associated arthropathy that occurs within several weeks following a genitourinary or enteric infection.  It belongs to the group of seronegative spondyloarthropathies (including ankylosing spondylitis) and can cause sacroiliitis in about 20% of cases.

A 17-Year-Old Boy Is Brought to the Physician Because of a 12-Day