A 42-year-old man is brought to the physician because of progressive memory loss. His wife reports that he often misplaces his possessions and has begun writing notes to remind himself of names and important appointments. He was diagnosed with HIV 7 years ago, but his medical follow-up and treatment compliance have been poor. His temperature is 37.8°C (100°F), pulse is 82/min, respirations are 16/min, and blood pressure is 144/88 mm Hg. Examination shows confluent white plaques on the posterior oropharynx. Neurologic examination shows mild ataxia and an inability to perform repetitive rotary forearm movements. After couples of week, the patient dies due to motor accident. Which of the following histopathologic findings would most likely be found on biopsy of this patient's brain?

Question

A 42-year-old man is brought to the physician because of progressive memory loss. His wife reports that he often misplaces his possessions and has begun writing notes to remind himself of names and important appointments. He was diagnosed with HIV 7 years ago, but his medical follow-up and treatment compliance have been poor.  His temperature is 37.8°C (100°F), pulse is 82/min, respirations are 16/min, and blood pressure is 144/88 mm Hg. Examination shows confluent white plaques on the posterior oropharynx. Neurologic examination shows mild ataxia and an inability to perform repetitive rotary forearm movements. After couples of week, the patient dies due to motor accident. Which of the following histopathologic findings would most likely be found on biopsy of this patient's brain?

Quizplus · Accepted Answer

Eductional Objective: HIV-associated dementia should be suspected in patients with AIDS who have progressive cognitive decline.  The characteristic histopathologic finding is microglial nodules (groups of activated microglia/macrophages around small areas of necrosis) and multinucleated giant cells.

A 42-Year-Old Man Is Brought to the Physician Because of Progressive