A 17-year-old boy comes to the physician because of a history of weakness in his legs. He is concerned because he has had difficulty running and keeping up with peers for the past several years. He has a family history of same symptoms and his father uses wheelchair. Examination shows decreased muscle strength in the distal muscles of the lower extremities. Abnormal function of which of the following is the most likely cause of this patient's condition?

Question

Quizplus · Accepted Answer

Eductional Objective: Charcot-Marie-Tooth is a group of hereditary peripheral neuropathies characterized by mutations in genes coding for peripheral nerve axonal or myelin proteins.  Manifestations typically include progressive, symmetric distal muscle atrophy and weakness most prominent in the feet and calf musculature, with sensory loss, areflexia, pes cavus (ie, high arches), and hammer toes.

A 17-Year-Old Boy Comes to the Physician Because of a History