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A 27-Year-Old Woman Comes to the Physician for a Dull

Question 412

Multiple Choice

A 27-year-old woman comes to the physician for a dull aching pain and paresthesia over her left hand for the last few weeks. The pain radiates to her shoulder and is worse at night. Her hand feels numb upon waking up in the morning. Vital signs are within normal limits. When the wrist is passively held in full flexion, aggravation of paresthesia is perceived immediately. Which of the following is the most likely mechanism of this patient's condition?


A) Endomysial inflammatory infiltration
B) Endoneural arteriole hyalinization
C) Endoneural multifocal demyelination
D) Mutations of a muscle structural protein gene
E) Nerve compression within an anatomic compartment

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