A 32-year-old woman comes to the office due to recent fatigue and weight gain. She has no medical histrory and takes no medication. Blood pressure is 115/65 mm Hg and pulse is 85/min. On physical examination, there is a diffuse neck swelling with no palpable nodules, she says her neck has gradually gotten larger, and she does not like how it appears in the mirror. Serum TSH and free thyroxine levels are normal. She has a sister with vitiligo. There is no history of head and neck irradiation. Antibodies against thyroid peroxidase are present in high titers. Biopsy of this patient's thyroid is most likely to show which of the following findings?

Question

A 32-year-old woman comes to the office due to recent fatigue and weight gain. She has no medical histrory and takes no medication. Blood pressure is 115/65 mm Hg and pulse is 85/min. On physical examination, there is a diffuse neck swelling with no palpable nodules, she says her neck has gradually gotten larger, and she does not like how it appears in the mirror. Serum TSH and free thyroxine levels are normal. She has a sister with vitiligo. There is no history of head and neck irradiation.  Antibodies against thyroid peroxidase are present in high titers.   Biopsy of this patient's thyroid is most likely to show which of the following findings?

Quizplus · Accepted Answer

Eductional Objective: Chronic lymphocytic (Hashimoto) thyroiditis is a common cause of primary hypothyroidism.  Histopathology findings include intense lymphoplasmacytic infiltrate, often with germinal centers.  Residual follicles may be surrounded by Hürthle cells (large cells with granular, eosinophilic cytoplasm).

A 32-Year-Old Woman Comes to the Office Due to Recent