A 35-year-old guy who first observed nontender cervical lymphadenopathy while shaving is currently undergoing evaluation. Following a biopsy, the histology of the lymph nodes may be seen in the low-magnification picture below. Which of the following patterns would be most likely to be seen using cytogenetic analysis?

Question

A 35-year-old guy who first observed nontender cervical lymphadenopathy while shaving is currently undergoing evaluation. Following a biopsy, the histology of the lymph nodes may be seen in the low-magnification picture below.  Which of the following patterns would be most likely to be seen using cytogenetic analysis?

Quizplus · Accepted Answer

Eductional Objective: Aggregates of tightly packed follicles that cover over the typical lymph node architecture are the hallmark of follicular lymphoma. The t(14;18) translocation, which results in the antiapoptotic BCL-2 protein being overexpressed, is present in 90% of individuals with follicular lymphoma.

A 35-Year-Old Guy Who First Observed Nontender Cervical Lymphadenopathy While