A research center studying cardiovascular pathology is conducting trials in which experimental rabbits are fed sweet peas containing substances that alter connective tissue synthesis and maturation. The animals are monitored for several weeks prior to euthanasia. Autopsy shows myxomatous degeneration with pooling of proteoglycans in the media layer and an intact intima layer in large arteries. The pathologic findings seen in the experiment are most similar to which of the following conditions?

Question

A research center studying cardiovascular pathology is conducting trials in which experimental rabbits are fed sweet peas containing substances that alter connective tissue synthesis and maturation.  The animals are monitored for several weeks prior to euthanasia.  Autopsy shows myxomatous degeneration with pooling of proteoglycans in the media layer and an intact intima layer in large arteries.  The pathologic findings seen in the experiment are most similar to which of the following conditions?

Quizplus · Accepted Answer

Eductional Objective: Myxomatous changes, with pooling of mucopolysaccharides in the media layer of large arteries, are found in cystic medial degeneration, which predisposes affected patients to the development of aortic aneurysms.  Medial degeneration in younger individuals is frequently due to Marfan syndrome.

A Research Center Studying Cardiovascular Pathology Is Conducting Trials in Which