A 16-year-old boy comes to the physician because his parents are concerned about gynecomastia. Physical examination shows bilateral gynecomastia, sparse pubic hair. Genital examination shows microphallus and bilateral swelling in the groin region.. Serum studies show increased levels of luteinizing hormone and normal follicle-stimulating hormone and an increased serum testosterone. Semen analysis reveals severe oligospermia. Which of the following mechanisms is the most likely cause of this patient's condition?

Question

A 16-year-old boy comes to the physician because his parents are concerned about gynecomastia. Physical examination shows bilateral gynecomastia, sparse pubic hair. Genital examination shows microphallus and bilateral swelling in the groin region.. Serum studies show increased levels of luteinizing hormone and normal follicle-stimulating hormone and an increased serum testosterone. Semen analysis reveals severe oligospermia.  Which of the following mechanisms is the most likely cause of this patient's condition?

Quizplus · Accepted Answer

Eductional Objective: Androgen receptor dysfunction in patients with partial androgen insensitivity syndrome leads to decreased facial, axillary, and pubic hair; oligospermia; gynecomastia; and undervirilization of external genitalia (eg, microphallus).  Loss of feedback inhibition of gonadotropin-releasing hormone results in elevated LH and testosterone levels.

A 16-Year-Old Boy Comes to the Physician Because His Parents