After a tumble, a 27-year-old lady arrives at the emergency department with a scalp laceration. She claims that even little injuries result in large scars. As depicted in the image below, a physical examination reveals an old, healed wound. 1 Her tissue histochemical study revealed fibroblasts that overexpress a cytokine required for proper wound healing. Which of the following is the most likely culprit?

Question

After a tumble, a 27-year-old lady arrives at the emergency department with a scalp laceration. She claims that even little injuries result in large scars. As depicted in the image below, a physical examination reveals an old, healed wound. 1  Her tissue histochemical study revealed fibroblasts that overexpress a cytokine required for proper wound healing. Which of the following is the most likely culprit?

Quizplus · Accepted Answer

Eductional Objective: TGF-Beta (transforming growth factor) is required for fibroblast migration, proliferation, and connective tissue production. Chronic inflammation causes hypertrophic/keloid scarring and fibrosis of the lung, liver, and kidney due to increased TGF-Beta activity.

After a Tumble, a 27-Year-Old Lady Arrives at the Emergency