A 19-year-old woman comes to the physician for evaluation due to abrupt lose her muscle control. She has had several similar episodes of transient generalized weakness over the past month, once during an argument with her mother and another time while watching her favorite comedy movie. She has also had excessive daytime sleepiness for 18 months despite 9 hours of sleep nightly and 2 daily naps. She has fallen asleep in class several times. She often sees intensely bright colors as she is falling asleep. During this time, she is often unable to move; this inability to move is very distressing to her. If measured, which of the following compounds is most likely to be abnormal in this patient's cerebrospinal fluid?

Question

A 19-year-old woman comes to the physician for evaluation due to abrupt lose her muscle control. She has had several similar episodes of transient generalized weakness over the past month, once during an argument with her mother and another time while watching her favorite comedy movie. She has also had excessive daytime sleepiness for 18 months despite 9 hours of sleep nightly and 2 daily naps. She has fallen asleep in class several times. She often sees intensely bright colors as she is falling asleep. During this time, she is often unable to move; this inability to move is very distressing to her.   If measured, which of the following compounds is most likely to be abnormal in this patient's cerebrospinal fluid?

Quizplus · Accepted Answer

Eductional Objective: Hypocretin-1 (orexin-A) and hypocretin-2 (orexin-B) are neuropeptides produced in the lateral hypothalamus that promote wakefulness and inhibit REM sleep-related phenomena.  Most patients who have narcolepsy with cataplexy have undetectable levels of hypocretin-1 in their cerebrospinal fluid.

A 19-Year-Old Woman Comes to the Physician for Evaluation Due