A 34-year-old woman arrives at the office with a one-year history of wrist and hand pain and swelling. There are no other medical conditions or medications that the patient is taking. Vital signs are typical. There are no wrinkles on the face or neck. The exhibit includes a photograph of her left hand. Interplay among which of the following cells is most likely responsible for this patient's condition?

Question

A 34-year-old woman arrives at the office with a one-year history of wrist and hand pain and swelling. There are no other medical conditions or medications that the patient is taking. Vital signs are typical. There are no wrinkles on the face or neck. The exhibit includes a photograph of her left hand.  Interplay among which of the following cells is most likely responsible for this patient's condition?

Quizplus · Accepted Answer

Eductional Objective: Systemic sclerosis (scleroderma) is caused by increased expression of endothelin 1 and adhesion molecules in vascular endothelial cells, T lymphocytes (production of cytokines that activate fibroblasts), and dermal fibroblasts (increased production of collagen and ground substance).

A 34-Year-Old Woman Arrives at the Office with a One-Year