A 44-year-old man is brought to the hosiptal after his wife found him unresponiveness. He has a history of opioid and alcohol intoxication. While unconscious, he vomited profusely and then rapidly developed hypoxia and shortness of breath that has continued to worsen. Temperature is 38.4 C (101.1 F), blood pressure is 108/74 mm Hg, pulse is 120/min, and respirations are 26/min. Diffuse crackles are heard on auscultation. The extremities are warm, well perfused, and without edema. Chest x-ray reveals bilateral alveolar opacities. The results of arterial blood gas analysis on room air are as follows: Which of the following pathologic processes is the primary contributor to this patient's lung findings?

Question

A 44-year-old man is brought to the hosiptal after his wife found him unresponiveness. He has a history of opioid and alcohol intoxication.  While unconscious, he vomited profusely and then rapidly developed hypoxia and shortness of breath that has continued to worsen.  Temperature is 38.4 C (101.1 F), blood pressure is 108/74 mm Hg, pulse is 120/min, and respirations are 26/min.  Diffuse crackles are heard on auscultation.  The extremities are warm, well perfused, and without edema.  Chest x-ray reveals bilateral alveolar opacities.  The results of arterial blood gas analysis on room air are as follows:  Which of the following pathologic processes is the primary contributor to this patient's lung findings?

Quizplus · Accepted Answer

Eductional Objective: Acute respiratory distress syndrome involves acute neutrophilic lung inflammation with widespread alveolar damage due to proteases and reactive oxygen species, leading to failure of the vascular barrier and exudative pulmonary edema.

A 44-Year-Old Man Is Brought to the Hosiptal After His