Two weeks after undergoing allogeneic stem cell transplant for multiple myeloma, a 55-year-old man develops a severely pruritic rash, abdominal cramps, and profuse diarrhea. He appears lethargic. Physical examination shows yellow sclerae. There is a generalized maculopapular rash on his face, trunk, and lower extremities, and desquamation of both soles. If this patient received a conditioning chemotherapy and radiotherapy before the stem cell transplant this will decrease risk which of the following?

Question

Quizplus · Accepted Answer

Eductional Objective: Allogeneic hematopoietic stem cell grafts normally include donor CD3+ T cells that can initiate graft versus host disease (GVHD), a widespread inflammatory response that can damage multiple organs. Depletion of donor CD3+ T cells prior to transplant decreases the risk of GVHD but also decreases the beneficial graft versus tumor effect, increasing the likelihood of cancer relapse.

Two Weeks After Undergoing Allogeneic Stem Cell Transplant for Multiple