A 32-year-old woman comes to the physician because of flank pain, myalgia, and reddish discoloration of her urine for the past 2 days. She is otherwise healthy and has no history of serious illness. Her younger sister has sickle cell disease. Her temperature is 37.9°C (100.2°F), pulse is 70/min, and blood pressure is 128/75 mm Hg. Physical examination shows a soft abdomen and no costovertebral angle tenderness. . There is a faint maculopapular rash over the trunk and extremities. Serum creatinine is 2.4 mg/dL. Which of the following is the most likely cause of this patient's hematuria?

Question

A 32-year-old woman comes to the physician because of flank pain, myalgia, and reddish discoloration of her urine for the past 2 days. She is otherwise healthy and has no history of serious illness.   Her younger sister has sickle cell disease. Her temperature is 37.9°C (100.2°F), pulse is 70/min, and blood pressure is 128/75 mm Hg. Physical examination shows a soft abdomen and no costovertebral angle tenderness. . There is a faint maculopapular rash over the trunk and extremities. Serum creatinine is 2.4 mg/dL. Which of the following is the most likely cause of this patient's hematuria?

Quizplus · Accepted Answer

Eductional Objective: Renal papillary necrosis classically presents with gross hematuria, acute flank pain, and passage of tissue fragments in urine.  It is most commonly seen in patients with sickle cell disease or trait, diabetes mellitus, analgesic nephropathy, or severe obstructive pyelonephritis

A 32-Year-Old Woman Comes to the Physician Because of Flank