A 68-year-old woman comes to the office due to increasing low back pain. The pain is constant and worsens at night. She has also had a 6.8-kg (15-lb) weight loss over the past 3 months. Medical history is significant for osteoporosis and hypothyroidism. Family history is significant for breast cancer in her mother. She has smoked 1 pack of cigarettes daily for 30 years and drinks 1 or 2 glasses of wine every day. Further evaluation of the patient reveals microscopic hematuria. Laboratory results are as follows: Which of the following is the most likely cause of this patient's hematologic findings?

Question

A 68-year-old woman comes to the office due to increasing low back pain.  The pain is constant and worsens at night.  She has also had a 6.8-kg (15-lb) weight loss over the past 3 months.  Medical history is significant for osteoporosis and hypothyroidism.  Family history is significant for breast cancer in her mother.  She has smoked 1 pack of cigarettes daily for 30 years and drinks 1 or 2 glasses of wine every day.  Further evaluation of the patient reveals microscopic hematuria.  Laboratory results are as follows:  Which of the following is the most likely cause of this patient's hematologic findings?

Quizplus · Accepted Answer

Eductional Objective: Renal cell carcinoma causes a variety of paraneoplastic syndromes including erythrocytosis (due to excessive erythropoietin production) and hypercalcemia (due to parathyroid hormone-related peptide).

A 68-Year-Old Woman Comes to the Office Due to Increasing